Hypersplenism Portal Hypertension

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Updated: May 17, 2022

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FAQs

1

Can portal hypertension cause hypersplenism?

Portal hypertension is a main cause of hypersplenism in CLD. In portal hypertension, splenic arterial blood flow increases and splenic venous flow into the portal vein is impeded by elevated portal pressure, which cause congestion of intrasplenic blood flow and spleen enlargement.
2

Why does cirrhosis cause hypersplenism?

During the progression of liver cirrhosis, the spleen-derived immune cells and cytokines may travel into the injured liver via portal blood flow. Together with the portal hypertension and congestion, this will result in splenomegaly and hypersplenism.
3

What are the four major clinical manifestation of portal hypertension?

The clinical manifestations of portal hypertension may include caput medusae, splenomegaly, edema of the legs, and gynecomastia (less commonly) (Figure 2). Caput medusae is a network of dilated veins surrounding the umbilicus.
4

What is the most common complication of portal hypertension?

Variceal hemorrhage is the most common complication associated with portal hypertension. Almost 90% of patients with cirrhosis develop varices, and approximately 30% of varices bleed.
2. Clinicaltrials.gov

Hypersplenism in Patients With Liver Cirrhosis and Portal ...

https://clinicaltrials.gov/ct2/show/NCT03269877

The spleen could be considered a neglected organ. To date, it has been deemed an ancillary organ in portal hypertension or an organ localization in ...

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