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Updated: May 17, 2022
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If you have had a severe allergic reaction to any ingredient in the Pfizer-BioNTech COVID-19 vaccine (such as polyethylene glycol), you should not get this vaccine. If you had a severe allergic reaction after getting a dose of the Pfizer-BioNTech COVID-19 vaccine, you should not get another dose of an mRNA vaccine.
Side effects from both the Moderna and Pfizer COVID-19 vaccines are more common after the second dose. This is because your immune system recognizes the virus spike protein from the first dose of the vaccine and mounts a stronger response.
Data released by the U.S. Food and Drug Administration (FDA) show that COVID-19 protection from the Pfizer/BioNTech vaccine was demonstrated in the clinical trials at about 14 days after the first shot. The FDA said some level of immunity may start sooner, but how much is not certain.
You should get your second shot as close to the recommended 3-week or 4-week interval as possible. You should not get the second dose early.
Visit the Pfizer for Professionals site for access to product information & sample ordering, resources, patient assistance programs, and customer service.
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